Job Opportunities

Research Scientist, Translational Science

Reports to: Pharmacology and Translational Science
Location: Cranbury, NJ

About PMV Pharmaceuticals

PMV Pharma is a precision oncology company pioneering the discovery and development of small molecule, tumor-agnostic therapies targeting the reactivation of p53 mutants. p53 mutations are found in approximately half of all cancers. The field of p53 biology was established by our co-founder Dr. Arnold Levine when he discovered the p53 protein in 1979. Bringing together leaders in the field to utilize over four decades of p53 biology, PMV Pharma combines unique biological understanding with pharmaceutical development focus.  PMV Pharma is headquartered in Cranbury, New Jersey. For more information, please visit www.pmvpharma.com.

Responsibilities

  • Characterization of lead compounds in cellular assays
  • Adaptation/optimization of cell-based assays used to measure in vivo samples
  • Analysis and interpretation of pharmacodynamic assays performed on in vivo samples
  • Studies to support the translation of lead molecules to the clinic, for example: generation and analysis of samples to test on clinical contract lab platforms, combination studies in vitro (anti-proliferation and MOA studies), generation of resistant cell lines and characterization
  • Basic bioinformatics, ability to interrogate public and private databases to understand mutation frequencies and demographics
  • Participation in discovery biology and clinical biomarker team meetings

Requirements

  • BS/MS with 5+ years of industry experience in the field of cancer biology
  • Working knowledge of in vivo models utilized in immuno-oncology (no hands-on animal work)
  • Experience with a range of in vitro assays including RT-PCR (single and multiplex), ELISA/MSD design and optimization, Western analysis, immunohistochemistry
  • A good knowledge of tumor signaling pathways
  • Working knowledge of database interrogation (e.g: CBio, Broad, DepMap)
  • Ability to work in alignment with PMV and manager to drive research projects by successfully designing, executing, and interpreting experiments
  • Proven track record of successful scientific accomplishments, presentations and/or peer reviewed publications

Attributes

  • Outstanding scientific capabilities to design, execute and interpret key experiments
  • Methodical and committed to high-quality results
  • Excellent communication and presentation skills
  • Ability to be productive and successful in a fast-paced work environment
  • Motivated team player able to work closely with others to solve complex problems

How to Apply

To apply, please submit your cover letter and resume to Recruiting@pmvpharma.com.


PLEASE, NO PHONE CALLS or AGENCIES

PMV Pharmaceuticals is an Equal Opportunity Employer and all applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.