Research Scientist – In Vivo Pharmacology
The successful candidate will possess hands-on experience in vivo pharmacology including cell culture handling and dosing laboratory mice/rats, and collection of a variety of tissues (e.g. blood, tumor etc) after euthanasia.
ESSENTIAL DUTIES AND RESPONSIBILITIES:
- In vitro cell culture of human and mouse cancer cell lines
- Monitor daily animal health and welfare while performing daily animal health observations.
- Ability to restrain, handle and manipulate mice and rats as assigned including dosing rodents by PO/IV/IP/SC routes.
- Independently execute in vivo pharmacology studies to demonstrate efficacy and characterize mechanism of action (PD/PK) of lead molecules in various rodent models of cancer.
- Interprets and communicates results as part of multi-disciplinary team(s).
- Abides by all safety and regulatory guidelines.
- Keeps accurate records and enters data into an electronic laboratory notebook in a timely manner.
- Assists with routine husbandry tasks as needed.
- Performs other duties as assigned.
- Education: M.S. with minimum 1+ years, or B.S. with minimum 3+ years pharmaceutical industry experience executing in vivo pharmacology studies with immunocompetent and immunocompromised animals in oncology.
- Experience using multiple types of in vivo oncology models (immunocompetent and immunocompromised mouse models, etc.)
- Experience with genetically engineered mouse models (i.e. colony maintenance, breeding, weaning, PCR genotyping).
- Superior technical expertise with standard in vivo techniques, including dosing and sampling routes (e.g., po, ip, sc, iv dosing; submandibular, retro-orbital, cardiac bleeds; necropsy and organ/tumor harvest) and tumor measurements is required.
- Competency with mouse surgical techniques (orthotopic implants, etc.) will also be highly valued.
- Expertise with the aseptic culture of mammalian cells (cell lines and primary cells), including propagating cultures and freezing cells.
- Experience with ex vivo techniques and analysis (tissue extraction, single cell dissociation) will be highly valued.
- Experience with IACUC and AAALAC.
- Experience and proficiency in working with data/statistical analysis software packages such as GraphPad/Prism
KNOWLEDGE, SKILLS AND ABILITIES:
- Must be able to follow verbal and written instructions and exhibit interpersonal skills that are conducive to effective communication and that contribute to a congenial work environment. Maintain positive work atmosphere by behaving and communicating in a professional manner with clients, customers, coworkers, and supervisors.
- Ability to read, write, speak and understand English.
- While performing the duties of this job, the employee is regularly required to stand; use hands to finger, handle, or feel objects, tools, or controls; and reach with hands and arms. The employee frequently is required to walk and stoop, kneel, crouch, or crawl. The employee is occasionally required to sit.
- The employee must regularly lift and/or move up to 50 pounds.
- Specific vision abilities required by this job include close vision, distance vision, peripheral vision, depth perception, and the ability to adjust focus.
- While performing the duties of this job, the employee frequently works near moving mechanical parts; is exposed to fumes or airborne particles, laboratory animal caging of various species including mice and rats and is occasionally exposed to wet and/or humid conditions, toxic or caustic chemicals, biohazard materials/agents, infectious disease and risk of electrical shock.
- The noise level in the work environment is usually moderate.
- Normally 40 hours per week. Will be required to work some weekends and non-traditional business hours to complete duties.
How to Apply
To apply, please submit your cover letter and resume to Recruiting@pmvpharma.com.
PLEASE, NO PHONE CALLS or AGENCIES
PMV Pharmaceuticals is an Equal Opportunity Employer and all applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.