Arnold Levine, Ph.D.
Co-Founder & Member, Scientific Advisory Board
Arnold J. Levine is currently a Professor Emeritus at The Simons Center for Systems Biology at the Institute for Advanced Study in Princeton, and a joint Professor in the Pediatrics and Biochemistry Departments at the Cancer Institute of New Jersey. He received his B.A. in Biology from Harpur College, SUNY and his Ph.D. from the University of Pennsylvania.
He trained as a Postdoctoral Fellow at California Institute of Technology in the laboratory of Robert Sinsheimer. Dr. Levine is a widely acclaimed leader in cancer research. In 1979, Dr. Levine and others discovered the p53 tumor suppressor protein, a molecule that inhibits tumor development. He established the Simons Center for Systems Biology at the Institute for Advanced Study, which concentrates on research at the interface of molecular biology and the physical sciences: on genetics and genomics, polymorphisms and molecular aspects of evolution, signal transduction pathways and networks, stress responses, and pharmacogenomics in cancer biology. Dr. Levine helped shape U.S. science priorities as chairman of an influential 1996 review panel on federal AIDS research funding. He also chaired the National Cancer Advisory Board, which advises the National Academy of Sciences and its Institute of Medicine on cancer policy. He was elected to the National Academy of Sciences in 1991 and to its Institute of Medicine in 1995. In April 2001, Levine received the first Albany Medical Center Prize in Medicine and Biomedical Research, the largest annual prize in science or medicine offered in the United States. In 1968 Dr. Levine joined Princeton University as an Assistant Professor, becoming a Professor of biochemistry in 1976. In 1979, he moved to the SUNY Stony Brook School of Medicine to Chair the Department of Microbiology. He returned to Princeton in 1984. Between 1984 and 1996, he presided over a major expansion of Princeton’s life sciences programs as Chairman of the Department of Molecular Biology. From 1998 to 2002, Dr. Levine was President of The Rockefeller University.
Thomas Shenk, Ph.D.
Co-Founder & Member, Scientific Advisory Board
Thomas Shenk, Ph.D., is the James A. Elkins Professor of Life Sciences in the Department of Molecular Biology at Princeton University. He received his B.S. in Biology from the University of Detroit and his Ph.D. in Microbiology from Rutgers University. He trained as a Postdoctoral Fellow in Molecular Biology at Stanford University in the laboratory of Paul Berg.
Dr. Shenk is a virologist, who has investigated gene functions and pathogenesis of adenovirus, a DNA tumor virus, and human cytomegalovirus, a member of the herpes family of viruses. His laboratory’s current areas of focus include the dissection of cytomegalovirus gene functions, persistence, and latency. Dr. Shenk is the recipient of the Eli Lilly Award from the American Society for Microbiology, an American Cancer Society Professorship and an Investigatorship from the Howard Hughes Medical Institute. He is a fellow of the American Academy of Microbiology, the American Academy of Arts and Sciences and the American Association for the Advancement of Science; and he is a member of the U.S. National Academy of Sciences and the U.S. Institute of Medicine. Dr. Shenk served as Chair of Princeton’s Department of Molecular Biology for two terms. He has served as editor-in-chief of the Journal of Virology and as Chair of the Council for Research and Clinical Investigation of the American Cancer Society. He is a past President of the American Society for Virology and the American Society for Microbiology, and he served on the Board of Directors of Merck & Company for 11 years. He currently serves as a member of the Board of Directors of the Fox Chase Cancer Center and the Hepatitis B Foundation.
David H. Mack, Ph.D.
Co-Founder, President & CEO
Prior to co-founding PMV Pharma with biologists Arnold Levine and Thomas Shenk, Dr. Mack was a general partner at Alta Partners from 2002 to 2013. His first investment was Angiosyn (acquired by Pfizer in 2005) where he was a Director and CEO. Prior to Alta, Dr. Mack co-founded and served as Vice President of Genomics Research at Eos Biotechnology (acquired by Protein Design Labs in 2003).
From 1994 to 1997, he served at Affymetrix as Head of Cancer Biology where he oversaw the development and application of DNA array technology in the areas of oncology and inflammation. Dr. Mack was also a pivotal member of the Polymerase Chain Reaction (PCR) Invention Group at Cetus (now Novartis) in the mid 1980s. Dr. Mack has co-authored more than 30 scientific articles and reviews, including papers published in Cell, Science, and Nature, and is an inventor on 26 issued US patents. Dr. Mack was an American Cancer Society Postdoctoral Fellow in microbiology and immunology at Stanford University School of Medicine. He received his Ph.D. from the University of Chicago, where he was a Howard Hughes Fellow in Molecular Genetics and Cell Biology, and a B.A. in Molecular Biology from the University of California, Berkeley.
Binh Vu, Ph.D.
Vice President, Chemistry
Prior to joining PMV Pharma as Director of Research, Dr. Vu was a Research Leader at Roche Nutley where he spent 15 years working in small molecule oncology drug discovery. While at Roche, Dr. Vu was a key contributor to the discovery and development of Nutlins, small molecule MDM2 antagonists which target the p53 pathway. He has extensively published on p53 biology and drug discovery, and is an inventor on 14 issued US patents.
Dr. Vu received a Ph.D. in Chemistry from the University of California, Los Angeles, and completed an NIH Postdoctoral Fellowship at the University of Texas at Austin. He received a B.S. in Chemistry from the University of California, Irvine.
Thomas Davis, Ph.D.
Vice President, Biology
Dr. Davis joined PMV Pharma as Vice President of Biology after 13 years at PTC Therapeutics where he was responsible for building and developing the Oncology portfolio. While at PTC, Dr. Davis' group developed three drug candidates, two of which (PTC299 and PTC596) have entered clinical trials. His industry experience began at Pharmacia Corporation, where he led a team tasked with expanding the selective COX2 inhibitor celecoxib (Celebrex, Pfizer) into the oncology arena. Dr. Davis has co-authored over 20 manuscripts and is an inventor on over 10 issued US patents.
Dr. Davis received a Ph.D. in Microbiology and Immunology from the University of Kentucky, and completed a Postdoctoral Fellowship at the University of Wisconsin, Madison. He received a B.S. in Microbiology from Iowa State University.